There are different terms to which flow chemistry is known for which would be microchemistry, plug flow or continuous flow chemistry that is considered to as the process of performing chemical reactions in a pipe or a in a tube. Reactive components in fact are being pumped together by a mixing junction and flowed down through a temperature controlled pipe or tube.
One of the big advantage when it comes to flow chemistry is on the cleaner products, fast reaction, quick reaction optimization, safer reactions, easy scale-up and also on the integration of separate process like work-up, synthesis and analysis. Visit the website of an expert like
Flow chemistry could actually give different benefits. This also comes with faster reactions where its reactors can also be pressurizes easily. This will allow reactions to be heated above its normal boiling point which then creates reaction rates which are thousand times faster. This process is known commonly as superheating.
The flow reactors also is able to enable good reaction selectivity. The rapid diffusion mixing is able to help avoid issues which are found in batch reactors. High surface areas to volume rations enables an almost instantaneous heating or cooling which leads to an ultimate temperature control.
also allows only a small amount of hazardous intermediate in forming any time in an instant. A high surface area likewise allow excellent control to exotherms.
This also has an integrated synthesis, work-up and analysis as well. Reaction products exiting a flow reactor could be flowed to a flow aqueous work-up system or to a solid phase scavenger column. From there, it could then be analyzed in a line or through a sample taken using a sampler and a dilutor then injected to the LCMS.
Flow chemistry also have a rapid reaction optimization. Flow chemistry that comes with automation enables quick variation on reaction conditions on a small scale. The parameters like temperature, reaction time, ration of reagents, concentration and reagents themselves can all be varied rapidly. A single reaction can actually follow another, separated by solvent each of them cleaning out the previous reaction.
Flow chemistry have easy scale-up as well. The scale up issues are in fact being minimized due to maintaining an excellent mixing and heat transfer. The higher flow rates and larger reactors could be used in order to easily produce kilogram quantities.
With the use of the microreactor technology, it will be able to speed up more the development and the up-scaling in a more efficient way. The microreactors are in fact devices that are operating through a continuous flow that allows strict control of the reaction parameters to be able to control reactions which are otherwise hazardous, reactive or are exothermic. To get significant amounts on this kind of product, microreactors are not being scaled up yet the internal volumes of its actual channels are increased through a smart mechanical design and its reactors are likewise numbered up. Read more at